01
Backbone Free Energy
Maps stored mechanical strain encoded by backbone hydrogen-bond geometry.
BFE / STORED STRAINProtein mechanics, made visible
A new geometric language for protein dynamics.
Proteins do more than hold a shape. Their structures encode strain, susceptibility, and response. Moving Frame Tech reads that hidden mechanical architecture from geometry.
STRUCTURE 01
HIDDEN MECHANICS 02
CANDIDATE SITES 03
GEOMETRYTHERMODYNAMICSFUNCTIONSCROLL TO EXPLORE ↓
01 / THE APPROACH
Read what a structure is ready to do.
Our platform brings together three complementary methods to examine how a protein stores mechanical energy, where it is predisposed to respond, and how that response changes under perturbation.
02
Fragility
Identifies where a native protein is mechanically predisposed to respond.
NATIVE SUSCEPTIBILITY03
Lability
Tracks how backbone strain redistributes after mutation, binding, or conformational change.
RESPONSE TO CHANGEFROM STRUCTURE TO INSIGHT
Find the regions that matter mechanically.
Geometry-guided analysis helps prioritize candidate residues, patches, and pathways before downstream molecule discovery or laboratory testing.
- 01Begin with structureExperimental structures or AlphaFold models
- 02Map hidden mechanicsBackbone Free Energy · Fragility · Lability
- 03Prioritize candidatesRegions and pathways for further study
02 / POSSIBILITIES
One framework. Many protein questions.
Where protein function, activity, or stability matters, understanding hidden mechanics offers a new starting point for research and development.
Therapeutic research
Investigate candidate intervention regions and mechanical pathways beyond conventional binding-site views.
Enzymes & biotechnology
Prioritize experimentally testable candidates for enzyme activity, robustness, and protein engineering.
Protein performance
Explore structure-guided strategies for stability, formulation, and product lifetime.
These are research and development opportunities; candidate effects require experimental validation.
03 / SCIENTIFIC FOUNDATION
Grounded in geometry and thermodynamics.
Moving Frame Tech’s methods are based on geometric and thermodynamic analysis rather than machine learning. They can examine experimentally determined structures as well as AlphaFold models.
The scientific work of Robert Penner at the Institut des Hautes Études Scientifiques (IHES), France, underpins the approach. International patent applications are pending.
FURTHER READINGPrincipia Geometrica Proteini: Backbone Strain and Functional GeometryRobert Penner · World Scientific
04 / COMPANY
Moving Frame Tech LLC
We are developing a new way to understand protein dynamics and function by revealing the mechanical information encoded in three-dimensional structure.
LEADERSHIP
Robert PennerFounder, President & CEO
François BachelierCTO & CIO
PLATFORM ACCESS
See proteins in a new frame.
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